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Leukotrienes, lipoxins
and platelet-activating factor are lipid mediators
of inflammation and potent activators of neutrophil
functional responses, including those related
to migration/chemotaxis such as adhesion molecule
expression, adhesion, enzyme secretion and locomotion.
Neutrophil migration from blood towards extravascular
space is an essential process of host defense
mechanisms. In this project, we investigate the
roles of the three classes of lipid mediators
in the regulation of neutrophil trafficking. In
a first approach, antagonists to the different
classes of mediators are used to modulate the
trafficking of neutrophils in in vitro and in
vivo models. A second approach implicates the
use of mice lacking receptors for the lipid mediators
(receptor knockout mice). Such studies will define
the role of the lipid mediators in the regulation
of neutrophil trafficking and might lead to the
development of novel anti-inflammatory drugs for
the treatment of diseases such as arthritis, psoriasis,
asthma, etc.
This
project is supported by
the Canadian Institutes of Health Research (CIHR).
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Mechanisms
of leukotriene biosynthesis 
