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  DIRECTOR
  Sylvain Bourgoin     
 
  RESEARCHERS
  Fawzi Aoudjit          
  Eric Boilard
  Pierre Borgeat        
  Maria Fernandes     
  Louis Flamand         
  Caroline Gilbert          
  François Marceau          
  Paul Naccache     
  Patrice Poubelle      
  Marc Pouliot            
  Patrick Provost        
  Raynald Roy            
  Jean Sévigny           
 
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Pierre BORGEAT, PhD
Professor, Department of Anatomy and Physiology, Faculty of Medicine, Université Laval.


Centre de Recherche en
Rhumatologie et Immunologie
2705, Boulevard Laurier, local T1-49
Quebec, QC
G1V 4G2 Canada
Tel: 418-656-4141 ext. 46166 (office)
Fax: 418-654-2765
E-mail:
Pierre.Borgeat@crchul.ulaval.ca

Research Themes | Research Projects | Selected References | List of Publications | Research Personnel | Additional Information

Academic Background
 

B.A. Collège des Jésuites, Quebec, 1967.

B.Sc. in Biochemistry, Université Laval, Quebec, Canada, 1971.

D.Sc. in Physiology, Laboratory of Dr. Fernand Labrie, Université Laval, Quebec, Canada, 1974.

Post-doctoral training in Chemistry, Laboratory of Prof. Bengt Samuelsson, Karolinska Institutet, Stockholm, Sweden, 1974-1976, 1978.

Post-doctoral training in Chemistry, Laboratory of Dr. Klauss Biemann, Massachusetts Institute of Technology, Boston, U.S.A., 1977.

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Reviews and Book Chapters
  Poubelle, P.E. and Borgeat, P. (2002) Platelet interactions with other cells related to inflammatory diseases. In: Platelets in thrombotic and non thrombotic disorders: pathophysiology, pharmacology and therapeutics. (Eds: P.Gresele, V.Fuster, C.P.Page and J.Vermylen) Cambridge University Press, Edinburgh, U.K. pp.869-884.

Flamand, N., Plante, H., Picard, S., Austin, M., Surette, M.E., Krump, E., Bourgoin, S., and Borgeat, P. (2001) Suppressive effects of adenosine on the 5-lipoxygenase pathway in human polymorphonuclear leukocytes. Drug Dev. Res. 52: 397-405.

Poubelle, P.E. and Borgeat, P. (2000) Perspectives thérapeutiques de l'inflammation. Médecine Sciences 16: 917-923.

Borgeat, P., Picard, S., Dallaire, N., Pouliot, M., Surette, M. (1999) Quantitative studies of the lipid mediators of inflammation using liquid chromatography-electrospray mass spectrometry. In: Molecular and Cellular Basis of Inflammation, Serhan, C.N. and Ward, P.A., eds. Humana Press, N.J., pp. 275-288.

Borgeat, P. (1997) Le mécanisme d'action anti-inflammatoire du Méthotrexate. Future Health/Perspectives Santé, Hiver 1997: 8-10.

Borgeat, P., Krump, E., Palmantier, R., Picard, S., Dallaire, N., McDonald, P., Pouliot, M., Surette, M.E., and McColl, S.R. (1997) The synthesis of leukotrienes by the human neutrophil. In: SRS-A to Leukotrienes. The Dawning of a new treatment. Holgate, S. and Dahlén, S.-V., eds., Blackwell Sciences, p. 69-84.

Borgeat, P. (1995) L'adénosine, un anti-inflammatoire naturel. Médecine/ Sciences 11: 294.

Borgeat, P., Picard, S., Braquet, P., Allen, M., and Shushan, B. (1994) LC-MS-MS with ion spray: a promising approach for analysis of underivatized platelet activating factor (PAF). J. Lipid Mediator Cell Signal. 10: 11-12.

Krump, E., Boudreault, S., Surette, M.E. and Borgeat, P. (1993) Effect of GM-CSF on leukotriene B4 synthesis in human neutrophils: facilitation of the priming effect by autologous plasma. In: "Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury". (S. Nigam, K. H. Honn and L. J. Marnett, eds.), Kluwer Academic Press, Boston, MA, USA.

Marleau, S., Fortin, C. and Borgeat, P. (1992) In vivo desensitization to leukotriene B4-induced neutrophil sequestration in rabbit lung. In: Eicosanoids and other bioactive lipids in cancer, inflammation and injury radiation. Nigam, S., Honn, K., Marnett, L., and Walden, T.L., eds., Kluwer Academic Publishers, pp. 261-263.

Smith, W.L., Borgeat, P. and Fitzpatrick, F.A. (1991) The eicosanoids: Cyclooxygenase, Lipoxygenase and Epoxygenase Pathways. In: New Comprehensive Biochemistry, Vol. 20, D.E. Vance and J.E. Vance, eds., Elsevier Science Publishers, N.Y., pp. 291-325.

Sirois, P., Prié, P., Laporte, J., Maghni, K. and Borgeat, P. (1991) Metabolism of arachidonic acid by purified lung epithelial cells. Proceeding of the XIth Washington International Spring Symposium. Prostaglandins, Leukotrienes, Lipoxins and PAF. Bailey, J.F., ed., pp. 225-232.

McColl, S.R., Krump, E., Naccache, P.H., Braquet, P., Poubelle, P. and Borgeat, P. (1989) Enhancement of platelet-activating factor-induced leukotriene synthesis in human neutrophils primed with granulocyte-macrophage colony-stimulating factor: effect of the ginkgolide BN52021. In: Ginkgolides, Chemistry, Biology, Pharmacology and Clinical Perspectives. Vol 2. (P. Braquet, ed.) J.R. Prous Science Publishers, S.A., pp. 75-82.

Naccache, P.H., Sha'afi, R.I. and Borgeat, P. (1989) Mobilization, metabolism and biological effects of eicosanoids in polymorphonuclear leukocytes. In: Neutrophil Physiology (M.B. Hallett, ed.), CRC Press, Boca Raton, FL., pp. 113-139.

Steffenrud, S., Borgeat, P. and Salari, H. (1988) Ion exchange high performance liquid chromatography leukotrienes. J. Liq. Chrom. 11: 849-862.

Borgeat, P., Nadeau, M., Rouleau, G., Sirois, P., Braquet, P. and Poubelle, P. (1988) PAF-induced leukotriene synthesis in human polymorpho-nuclear leukocytes: inhibition by Ginkgolide B (BN52021). In: The Ginkgolides: Chemistry, Biology, Pharmacology

Borgeat, P. (1987) Biochemistry of the leukotrienes. In: CRC Handbook of eicosanoids: prostaglandins and related lipids (A.L. Willis, ed), CRC Press, Boca Raton, FL., 193-210.

Sirois, P., Harczy, M., Maclouf, J., Pradelles, P., Braquet, P. and Borgeat, P. (1987) Lipid mediators in lung anaphylaxis: kinetics of their release and modulation by selected drugs. In: Lipid mediators in the immunology of shock (Paubert-Braquet, ed.), Plenum Press, New York, pp. 187-196.

Laviolette, M., Coulombe, R., Goldyne, M.E., Braquet, P., Picard, S. and Borgeat, P. (1987) Lipoxygenase-mediated metabolism of arachidonic acid in human alveolar macrophages: a study with cell suspensions and adherent cells. Ann. INSERM 152: 109-118.

Borgeat, P. (1986) Biochemistry of leukotrienes. In: The Leukotrienes: their biological significance (P. Piper, ed.), Raven Press, N.Y., pp. 1-14.

Poubelle, P., Beaulieu, A.D., Nadeau, M., Laviolette, M. and Borgeat, P. (1986) The metabolism of arachidonic acid through the lipoxygenase pathways in human phagocytes. In: Advances in Inflammation Research. Vol. 11 (Otterness, Lewis and Capetola, eds.), Raven Press, N.Y., pp. 17-30.

Braquet, M., Ducousso, R., Chapelat, M.-Y., Borgeat, P., DeFeudis, F.V. and Braquet, P. (1985) Transmembrane signal and eicosanoid release in the secretory process of A23187-stimulated leukocytes. In: Prostaglandins and other eicosanoids in the cardiovascular system (Schrör, ed.), Proc. 2nd Int. Symp., Nurnberg-Furth 1984, pp. 528-532.

Braquet, M., Lavaud, P., Dormont, D., Garay, R., Ducousso, R., Guilbaud, J., Chignard, M., Borgeat, P. and Braquet, P. (1985) Leukocytic functions in burn-injured patients. Prostaglandins 29: 747-764.

Maclouf, J., Maschio, A.D., Grange, M.J., Corvazier, E. and Borgeat, P. (1985) Regulation and manipulation of arachidonate cascade in cell-cell interaction. In: Advances in Prostaglandin, Thromboxane and Leukotriene Research, Vol. 15 (O. Hayaishi and S. Yamamoto, eds.), Raven Press, N.Y., pp. 209-211.

Salari, H., Borgeat, P., Braquet, P., Brousseau, Y. and Sirois, P. (1985) Release of leukotrienes B4 and D4 by the anaphylactic guinea pig lung in vitro. In: Prostaglandins, Leukotrienes and Lipoxines (J.M. Bailey, ed.), Plenum Press, pp. 511-517.

Smith, W.L. and Borgeat, P. (1985) The eicosanoids: prostaglandins, thromboxanes, leukotrienes and hydroxy-eicosaenoic acids. In: Biochemistry of lipids and membranes (D.E. Vance and J.E. Vance, eds.), Benjamin/Cummings, pp. 325-360.

Doherty, N., Poubelle, P., Borgeat, P., Beaver, T.H., Westrich, G.L. and Schrader, N.L. (1985) Intraperitoneal injection of zymosan in mice induces pain, inflammation and the synthesis of peptido-leukotrienes and prostaglandin E2. Prostaglandins 30: 769-789.

Borgeat, P. Sirois, P., Braquet, P. and Rola-Pleszczynski, M. (1985) Leukotrienes and inflammation. In: Biological protection with prostaglandins, Vol. 1 (M. Cohen, ed.), CRC Press, Boca Raton, FL., pp.13-26.

Braquet, P., Dorian, D., Borgeat, P., Defeudis, F.V. and Larrue, J. (1984) Transmembrane potassium movements, diuretic drugs and the arachidonic acid cascade: a study with cultured aortic smooth muscle cells. In: Diuretics, Chemistry, Pharmacology and Clinical Applications (J.B. Puschett and A. Greenberg, eds.), Elsevier (N.Y.) Pub., pp. 338-41.

Borgeat, P. (1984) Reversed-phase HPLC profiling and quantitation of lipoxygenase products. Prostaglandins 27: 356-358.

Steffenrud, S. and Borgeat, P. (1984) Derivatization of leukotrienes for gas chromatography-mass spectrometry. Prostaglandins 28: 593-596.

Braquet, M., Garay, M., Ducousso, R.G., Borgeat, P., Defeudis, F.V. and Braquet, P. (1984) Transmembrane potassium movements and the arachidonic acid cascade: I - A study in A23187 stimulated human leukocytes. In: Prostaglandins and Membrane Ion Transport (P. Braquet, R.P. Garay, J.C. Frölich and S. Nicosia, eds.), Raven Press, New York, pp. 1-14.

Sirois, P. and Borgeat, P. (1984) Les leucotriènes: nouveau médiateurs de l'asthme et de l'inflammation. L'Actualité Médicale, Janv. 30, 39-40, Févr. 13: 63-65.

Maclouf, J., Fruteau de Laclos, B. and Borgeat, P. (1983) Stimulation of 5-lipoxygenase activity in human blood leukocytes by 12-hydroperoxyeicosatetraenoic acid. In: Leukotrienes and other lipoxygenase products (P. Piper, ed.), John Wiley and Sons, London, pp. 90-93.

Borgeat, P., Fruteau de Laclos, B., Crastes de Paulet, A. and Maclouf, J. (1983) La biochimie des leucotriènes. Dans: Acquisitions rhumatologiques: Biochimie de l'inflammation (F. Blotman, A. Crastes de Paulet et L. Simon, eds.), Masson, Paris, 44-60.

Borgeat, P., Fruteau de Laclos, B., Ford-Hutchinson, A.W. and Sirois, P. (1983) Les leucotriènes: étape biologique nouvelle. La Revue de Médecine Thérapeutique 24: 61-67.

Corey, E.J., Hopkins, P.B., Barton, A.E., Bangerter, B. and Borgeat, P. (1982) Proton magnetic resonance spectra of leukotriene A methyl ester (I), leukotriene B methyl ester diacetate (II) and 12-epi-6-E,8-Z-leukotriene B methyl ester diacetate (III, 5-S,12-S-di-HETE). Tet. Letters 38: 2653-2657.

Labrie, F., Borgeat, P., Drouin, J., Lagacé, L., Giguère, V., Raymond, V., Godbout, M., Massicotte, J., Ferland, L., Barden, N., Beaulieu, M., Côté, J., Lépine, J. and Veilleux, R. (1982) The role of cyclic nucleotides in the control of anterior pituitary gland activity. In: Handbook of Experimental Pharmacology (J.A. Nathanson and J.W. Kebabian, eds.), Springer-Verlag, Berlin-Heidelberg, New York, Vol. 58, pp. 525-566.

Sirois, P. and Borgeat, P. (1982) Mediators of immediate hypersensitivity. In: Immunopharmacology (M. Rola-Pleszczynski and P. Sirois, eds.), Elsevier North-Holland, pp. 201-222.

Labrie, F., Borgeat, P., Barden, N., Godbout, M., Beaulieu, M., Ferland, L. and Lavoie, M. (1980) Mechanism of action of hypothalamic hormones in the anterior pituitary. In: 12th Miles Symposium, (R.F. Beers and E.G. Bassett, eds.), Raven Press, New York, pp. 235-252.

Labrie, F., Borgeat, P., Godbout, M. Beaulieu, M., Drouin, J., Lagacé, L. and Massicotte, J. (1980) Mechanisms of action of LHRH. Materia Medica Polona 12: 42-58.

Labrie, F., Godbout, M., Lagacé, L., Massicotte, J., Barden, N., Drouin, J., Lépine, J., Lissitzky, J.C., Raymond, V., Borgeat, P., Beaulieu, M. and Veilleux, R. (1980) Mechanism of action of hypothalamic hormones and interaction with peripheral hormones at the pituitary level. In: The Endocrine Function of the Brain (M. Motta, ed), Raven Press, New York, pp. 207-231.

Labrie, F., Godbout, M. Beaulieu, M., Borgeat, P. and Barden, N. (1979) Mechanism of action of hypothalamic hormones in the anterior pituitary gland. Trends Biochem. Sci. 4: 158-160.

Samuelsson, B., Hammarström, S. and Borgeat, P. (1979) Pathways of arachidonic acid metabolism. In: Advances in Inflammation Research, Vol. 1 (G. Weissmann, B. Samuelsson and R. Paoletti, eds.), Raven Press, New York, pp. 405-412.

Labrie, F., Borgeat, P., Beaulieu, M., Drouin, J., Lagacé, L. and De Léan, A. (1979) Mechanism of action of hypothalamic hormones. In: Clinical Neuroendocrinology, a pathophysiological approach, (G. Tolis, F. Labrie, J.B. Martin and F. Naftolin, eds.), Raven Press, New York, pp. 89-113.

Labrie, F., Borgeat, P., Drouin, J., Lagacé, L., Massicotte, J., Raymond, V. and Godbout, M. (1979) Mechanism of action of hypothalamic hormones in anterior pituitary gland and interaction with peripheral hormones. In: Biochemical endocrinology: synthesis and release of adenohypophyseal hormones: cellular and molecular mechanisms (K.W. McKerns and M. Jutisz, eds.), Plenum Press, pp. 415-439.

Labrie, F., Lagacé, L., Beaulieu, M., Ferland, L., De Léan, A., Drouin, J., Borgeat, P., Kelly, P.A., Cusan, L.,
Dupont, A., Lemay, A., Antakly, T., Pelletier, G. and Barden, N. (1979) Mechanism of action of hypothalamic and peripheral hormones in anterior pituitary gland. In: Hormonal Proteins and Peptides (C.H. Li, ed), vol. 9, Academic Press, pp. 205-277.

Labrie, F., Borgeat, P., Drouin, J., Lagacé, L., Beaulieu, M., De Léan, A., Dupont, A., Lemay, A., Belanger, A., Caron, M.G., Kelly, P.A. and Cusan, L. (1977) Mécanisme d'action des hormones hypothalamiques dans l'adénohypophyse et modulation de leur activité. In: Les neurohormones hypothalamiques, Comptes-Rendus du 41e Congrès Français de Médecine, Masson, pp. 37-58.

Labrie F., Drouin, J., Ferland, L., De Léan, A., Lagacé, L. and Borgeat, P. (1976) Mechanism of action of hypothalamic hormones and modulation of their activity. In: Proc. Vth Int. Congr. Endocrinology, (V.T. James, ed.), Excerpta Medica Int. Congr. Series, No. 402, pp. 168-174.

Drouin, J., Beaulieu, M., Borgeat, P., Ferland, L. and Labrie, F. (1976) Contrôle de la sécrétion des hormones adénohypophysaires. Revue de Médecine 32: 1717-1727.

Labrie, F., Borgeat, P., Ferland, L., Barden, N., Drouin, J., Beaulieu, M., Borgeat, P., De Léan, A. and Morin, O. (1976) Role of cyclic AMP in neuroendocrine control. In: Subcellular mechanisms in reproductive neuroendocrinology, (F. Naftolin, K.J. Ryan and I.J. Davies, eds.), ASP Biological and Medical Press, B.V. Elsevier Scientific Publishing Co., Excerpta Medica, Amsterdam, pp. 391-406.

Labrie, F., Ferland, L., Borgeat, P., Drouin, J., Beaulieu, M. and Schally, A.V. (1976) Mechanism of control of LH and FSH secretion. In: Proceedings of the First Int. Congr. on Human Reproduction, (A. Campos da Paz and A.V. Schally, eds.), Excerpta Medica Congress Series, no. 370, pp. 127-133.

Labrie, F., Pelletier, G., Borgeat, P., Drouin, J., Savary, M., Côté, J. and Ferland, L. (1976) Mode of action of hypothalamic regulatory hormones. In: Frontiers in Neuroendocrinology, vol. 4, (W.F. Ganong and L. Martini, eds.), Raven Press, New York, pp. 63-94.

Labrie, F., De Léan, A., Borgeat, P., Barden, N., Poirier, G. and Drouin, J. (1975) Polypeptide receptor mechanisms in anterior pituitary gland. In: Anatomical Neuroendocrinology, (W.E. Stumpf and L.D. Grant, eds.), S. Karger AG, Basel, pp. 62-68.

Labrie, F., Drouin, J., Borgeat, P., Ferland, L., Barden, N. and Bernard, J. (1975) Rôle des prostaglandines dans le contrôle de la sécrétion des hormones adénohypophysaires. In: Prostaglandines, Comptes-Rendus du 40e Congrès français de médecine, pp. 161-179.

Labrie, F., Borgeat, P., Ferland, L., Lemay, A., Dupont, A., Lemaire, S., Pelletier, G., Barden, N., Drouin, J., De Léan, A., Bélanger, A. and Jolicoeur, P. (1975) Mechanism of action and modulation of activity of hypothalamic hypophysiotropic hormones. In: Hypothalamic Hormones, (M. Motta, P.G. Crosignani et L. Martini, eds.), Acad. Press, pp. 109-123.

Labrie, F., Borgeat, P., Lemay, A., Lemaire, S., Barden, N., Drouin, J., Lemaire, I., Jolicoeur, P. and Bélanger, A. (1975) Role of cyclic AMP in the action of hypothalamic regulatory hormones. In: Advances in Cyclic Nucleotide Research, (G.I. Drummond, P. Greengard and G.A. Robinson, eds.), vol. 5, Raven Press, New York, pp. 787-801.

Ferland, L., Borgeat, P., Labrie, F., Bernard, J. and Raynaud, J.P. (1975) Changes of pituitary sensitivity to LHRH during the rat estrous cycle. Mol. Cell. Endocrinol. 2: 107-115.

Labrie, F., Pelletier, G., Borgeat, P., Drouin, J., Savary, M., Côté, J. and Ferland, L. (1974) Mechanism of action of luteinizing hormone-releasing hormone. In: Gonadotropins and Gonadal Functions (N.R. Moudgal, ed.), Academic Press, New York, pp. 292-304.

Borgeat, P., Labrie, F., Côté, J., Ruel, F., Schally, A.V., Coy, D.H., Coy, E.J. and Yanaihara, N. (1974) Parallel stimulation of cyclic AMP accumulation and LH and FSH release by analogs of LHRH in vitro. Mol. Cell. Endocrinol. 1: 7-20.

Labrie, F., Pelletier, G., Borgeat, P., Drouin, J., Savary, M., Côté, J. and Ferland, L. (1974) Mechanism of action of luteinizing hormone-releasing hormone (LHRH). In: Reproductive Physiology and Genetics (F. Fuchs and E.M. Coutinho, eds.), Plenum Press, vol. 1, pp. 289-305.

Borgeat, P., Poirier, G., Chavancy, G. and Labrie, F. (1973) Stimulation of adenohypophyseal adenylate cyclase activity by synthetic luteinizing hormone-releasing hormone (LHRH) and purified growth hormone (GHRH). (C. Gual and E. Rosemberg, eds.), Excerpta Medica Int. Congr. pp. 174-181.

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