The long-term objective is aimed at showing that during pathologic bone resorption of chronic inflammatory arthritides, such as that of rheumatoid arthritis, gout and chronic infectious arthritis, neutrophils could be potentially active in the excessive local bone resorption by activating directly or indirectly bone remodeling.

These projects are supported by the Canadian Institutes of Health Research (CIHR), National Institutes of Health (NIH/USA), The Arthritis Society (TAS) of Canada and Canadian Arthritis Network (CAN/RCA).

Chakravarti A., Allaeys I., Poubelle P.E. (2007) Neutrophile et immunité: est-ce inné ou acquis? Médecine/Sciences 23:862-7. PubMed

Chakravarti A., Marceau A.-A., Flamand L., Poubelle P.E. (2008) Normal human primary CD4+ T lymphocytes synthesize and release functional osteoprotegerin in vitro. Lab. Invest 88:171-84. PubMed

Chakravarti A., Raquil M.-A, Tessier P., Poubelle P.E. (2009) Surface RANKL of Toll-like receptor 4-stimulated human neutrophils activates osteoclastic bone resorption. Blood First Edition Paper, prepublished online June 22, 2009; DOI 10.1182/blood-2008-09-178301. Blood 114:1633-44. PubMed

Chakravarti A., Rusu D., Flamand N., Borgeat P., Poubelle P.E. (2009) Reprogramming of a subpopulation of human blood neutrophils by prolonged exposure to cytokines. Lab Invest: advance online publication, July 27, 2009; doi:10.1038/labinvest.2009.74 Lab Invest 89:1084-99. PubMed

Matron C., Chakravarti A., Allaeys I., Poubelle P.E. (2010) PKC-delta controls the fMLP-induced overproduction of superoxide by neutrophils. Free Radic Biol Med advance online publication,  doi:10.1016/j.freeradbiomed.2009.10.041. Free Radic Biol Med 48:207-15. PubMed

Poubelle P.E., A. Chakravarti, M.J. Fernandes, K. Doiron, A.-A. Marceau. (2007) Differential expression of RANK/RANK-L/OPG by synovial fluid neutrophils from patients with rheumatoid arthritis and normal human blood neutrophils. Arthritis Res Ther 9:R25. PubMed