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The identification of
new antigenic systems as well as better understanding the
immune response involved in the rejection phenomenon, are
the object of our research. Results of our team, presented
at the "14th International HLA Immunogenetics Workshop,
Melbourne 2005", showed for the first time the role of a
new antigenic system (MICA system), which could become as
important as the HLA system in the rejection of organ and
tissue grafts. Consequently, new criteria of recipient
selection, as well as new immunosuppressive therapies,
are being studied. These researches aim ultimately at
better characterisation of recipients at risk of rejection
while allowing therapeutic interventions that would
improve the care of future transplanted patients.
This
project is supported by The Kidney Foundation
of Canada, the Muscular Dystrophy Association
of Canada, the Muscular Dystrophy Association
of France, and the FRSQ's Eye Health Network.
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Skuk D., Roy B., Goulet M., Chapdelaine P., Bouchard J-P., Roy R., Dugré F.J., Lachance J-G., Deschênes L., Senay H., Sylvain M., Tremblay J-P. (2004) Dystrophin expression in myofibers of Duchenne muscular dystrophy patients following intramuscular injections of normal myogenic cells. Molecular Therapy , 9:475-482. PubMed
Bilrha H., Roy R ., Moreau B., Belles-Isles M., Dewailly É., Ayotte P. (2003) In vitro activation of cord blood mononuclear cells and cytokine production in a remote coastal population exposed to organochlorines and methyl mercury. Environ Health Perspect, 111:1952-1957. PubMed
Belles-Isles M., Ayotte
P., Dewailly É., Weber J-P., Roy R. (2002)
Cord blood lymphocyte functions in newborns from
a remote maritine population exposed to organochlorines
and methylmercury. J. Toxicology and Environmental
Health, 65:101-118. PubMed
Dugré F.J.,
Gaudreau S., Belles-Isles M., Houde I., Roy R.
(2000) Cytokine and cytotoxic molecule gene expression
determined in peripheral blood mononuclear cells
in the diagnosis of acute renal rejection. Transplantation,
70:1074-1080. PubMed
Roy R., Boisjoly H.M.,
Wagner E., Langlois A., Bernard P.-M., Bazin R,
Laughrea P.A., Dubé I. (1992) Pre and posttransplant
antibodies in human corneal transplantation. Transplantation,
54: 463-467. PubMed
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Transplantation
